Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome

Authors: Jason Lofters, Cassandra Chua, Jessica Moore, Bharath Miriyam, Augusta Alwang, Anish Vora, Renee Hodges, Tarun Aurora, Jane Hankins, Nickhill Bhakta, Robyn Cohen, Elizabeth Klings

Published: November 3, 2025

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Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial

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Application and challenges of the sickle cell outcome grading system (SCOGS) for classifying acute chest syndrome severity